AMPK Activator / Life Extension


Emulates Cell Energizing Effects of  Caloric Restriction

 활력 , 노화방지 및 뱃살지방 연소 



  • AMPK Activator
  • 30 vegetarian capsules


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AMPK is an enzyme that serves as the body's master regulating switch. 

AMPK 는 신진대사 를 조절하는 스위치 역활의 효소 입니다


It inhibits multiple damaging factors by revitalizing aging cells.1  

즉 노화세포 의  여러 손상요인 을 억제 하고 활성화 합니다.


Found in every cell,2,3 AMPK promotes longevity factors that have been shown to extend life span in numerous organisms.1,4 Increasing AMPK signaling "turns off" many damaging effects of aging, thus enabling cells to return to their youthful vitality.5

Life Extension® scientists have compiled years of research to create AMPK Activator, a specialized dual-extract formulation that supports AMPK activation for health optimization. This natural formula supports AMPK enzymatic activities required to safely support a more youthful cellular environment.  


다년간 연구결과 AMPK 의 활성화 는 보다 젊은세포 유지 ( 노화방지) 환경에 도움을 줍니다


최근 노화방지 작용 으로 갑자기 주목받는 당뇨약  메트포르민 (metformin) 과 AMPK 의 관계


메트포르민 ( metformin) 의 새로운 기전으로 간과 근육에서 AMPK (AMP-activated protein kinase)를 활성화시킨다는 것이

밝혀졌습니다.   그에 따르면 근육에서 AMPK를 활성화 함으로써 근육의 당 흡수를 증가시킵니다.

간에서는 AMPK 를 활성화 함으로써 지방 합성에 관련된 효소인 ACC의 활성이나 SREBP-1의 발현을 감소시키고

당신생을 억제하는 한편 지방 합성에 관여하는 효소들을 저하시켜 지방산의 산화를 증가시키고 VLDL의 합성을 억제하여

궁극적으로 지방간을 줄여주고 간의 인슐린 민감도를 높여줍니다.

Importance of AMPK

Greater AMPK (adenosine monophosphate-activated protein kinase) activation has been shown to help target damaging factors of aging.5 Studies show increased AMPK activity supports reduced fat storage,6 new mitochondria production,7 and the promotion of healthy blood glucose and lipids already within normal range.4

Gynostemma Pentaphyllum

An extract of the plant Gynostemma pentaphyllum was traditionally used in Asian medicine to promote longevity and scientists now know why—G. pentaphyllum promotes AMPK activation.8-10 In one of many studies showing a wide variety of benefits, researchers documented a 1-inch reduction in abdominal circumference in overweight individuals who took 450 mg daily of G. pentaphyllum extract for 12 weeks.11


Trans-tiliroside, extracted from plants such as rose hips, also boosts AMPK activation, but triggers different down­stream metabolic benefits than G. pentaphyllum.12-14  Among its many benefits, a low equivalent dose of 56 mg daily trans-tiliroside has been shown by researchers in preclinical studies to promote healthy blood glucose levels and body weight already within normal range.15

Anti-Aging Discovery that Cannot be Overlooked

Scientists uncovered the cell-energizing effect of AMPK in the 1970s. Since then, an exponential volume of data (over 7,500 published studies) documents the critical role that activated AMPK plays in maintaining life-sustaining cellular functions.

Those seeking to meaningfully extend their healthy life span should ensure they optimally activate their cellular AMPK. The reason this is so important is that in response to aging, excess calorie consumption, and/or low levels of physical activity, AMPK activity markedly declines.

A targeted way of reversing cellular depletion of this critical enzyme is to take the new AMPK Activator formula that comprises a dual-extract, plant-based formulation. 

This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.


1. J Mol Med (Berl). 2011 Jul;89(7):667-76.
2. J Proteome Res. 2011 Apr 1;10(4):1690-7.
3. Circ Res. 2007 Feb 16;100(3):328-41.
4. Physiol Rev. 2009 89:1025–78.
5. Age (Dordr). 2014 Apr;36(2):641-63.
6. Clin Sci (Lond). 2013 Apr;124(8):491-507.
7. Proc Natl Acad Sci USA. 2002 Dec 10;99 (25):15983-7.
8. Bioorg Med Chem. 2011 Nov 1;19(21):6254-60.
9. Carbohydr Polym. 2012 Jul 1;89(3):942-7.
10. Biotechnol Lett. 2012 Sep;34(9):1607-16.
11. Obesity (Silver Spring). 2014 Jan;22(1):63-71.
12. Diabetes Res Clin Pract. 2011 May;92(2):e41-6.
13. Prev Nutr Food Sci. 2013 Jun;18(2):85-91.
14. J Nutr Biochem. 2012 Jul;23(7):768-76.
15. Bioorg Med Chem Lett. 2007;17(11):3059-64.


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