Medical PPT/Urology

오예스좋아 2013. 2. 11. 23:35

 

이번에 소개할 방광의 양성 종양은 방광 유두종 (방광상피유두종, 이행상피유두종) 입니다. (Urothelial Papilloma)

지난 번에 보았던 Inverted papilloma에 이어, Papilloma와 비교하며 보시면 흥미롭게 볼 수 있을 듯 합니다.

 

방광 유두종은 암전이 가능성이 낮으며, 다음과 같은 특징을 지니는 양성 종양임을 이해하는 것이 핵심입니다.

1998년 WHO 분류에서 Grade I Ta Tumor로 분류 했다가 이제는 비침습성 양성 종양으로 구분이 바뀌었다는 점 기억하면 금상첨화 일것 같습니다. 이제 더이상 암으로 구분 안한다는 사실.

 

마찬가지로 PPT 발표자료와 함께 올립니다.

 

Papilloma of the bladder.ppt

 

 

Papilloma of the Bladder

 

 

 

 

•Uncommon, comprises ~1% of papillary urothelial neoplasms.

•Patients are typically <50 years old and can be seen in children.

•Often encountered as de novo lesion (without prior urothelial neoplasm).

•Cystoscopy shows a small unifocal papillary or elevated lesion.

•Recurrence rate of 9-31%, but with no risk for progression to higher-grade tumors.

 

•Histology:

 

   ◦Papillae (with fibrovascular core*) lined by normal-appearing urothelium, including presence of umbrella cells (image A) & (image B).
   ◦Nuclei elongated or oval.
   ◦Papillae are slender with minimal branching.

 * For any urothelial tumor to be called "papillary" the papillae should have a central fibrovascular core.

 

 

 

 

 

Benign proliferative growth in the bladder that is composed of delicate stalks lined by normal-appearing urothelium. Papillomas had previously been categorized as grade 1 Ta tumors of the bladder until the World Health Organization (WHO) changed the classification of noninvasive bladder cancer in 1998.
Papillomas rarely have mitotic figures and lack markers of aggressive growth such as TP53 or RB mutations, but 75% of these tumors will have mutations in the fibroblast growth factor receptor-3 (FGFR-3).
Papillomas may recur, but they do not progress or invade.

 

 

Referrence

1. Campbell Urology

Chapter 80 : Urothelial Tumors of the Bladder

 

Papilloma of the bladder.ppt

- 첨부파일

Papilloma of the bladder.ppt